7-Nitro-2-phenyl-1H-indole-5-carboxylic acid
7-Nitro-2-phenyl-1H-indole-5-carboxylic acid
CAS: 1120334-31-7
Molecular Formula: C15H10N2O4
7-Nitro-2-phenyl-1H-indole-5-carboxylic acid - Names and Identifiers
| Name | 7-Nitro-2-phenyl-1H-indole-5-carboxylic acid |
| Synonyms | 7-Nitro-2-phenyl-1H-indole-5-carboxylicacid 7-Nitro-2-phenyl-1H-indole-5-carboxylic acid |
| CAS | 1120334-31-7 |
7-Nitro-2-phenyl-1H-indole-5-carboxylic acid - Physico-chemical Properties
| Molecular Formula | C15H10N2O4 |
| Molar Mass | 282.25 |
7-Nitro-2-phenyl-1H-indole-5-carboxylic acid - Introduction
2-Phenyl-7-nitro-5-carboxylic acid indole is an organic compound often abbreviated as NDA. The following is a description of the nature, use, method and safety information of the NDA:
Nature:
-Appearance: NDA is a yellow crystalline solid.
-Solubility: NDA is soluble in organic solvents such as dichloromethane, dimethyl sulfoxide and dimethylformamide.
-Melting point: The melting point of NDA is about 212-215 degrees Celsius.
Use:
- NDA is an important organic synthesis intermediate, which has a wide range of applications in the fields of medicine and pesticide.
-It can be used to synthesize indole derivatives, which have anti-tumor, antibacterial and anti-inflammatory drug activities.
Preparation Method:
-One commonly used method of preparing NDA is to first alkylate indole under basic conditions to form 2-phenylindole. Then, 2-phenylindole is nitrated in the presence of a strong acid such as nitric acid and sulfuric acid to form 2-phenyl-7-nitro-indole in an oxidized state. Finally, through the carboxylation reaction under acidic conditions, the nitro group is oxidized to carboxyl, and the target product 2-phenyl -7-nitro -5-carboxylic acid indole is prepared.
Safety Information:
- NDA has low toxicity, but it still needs to be used and stored carefully, and follow relevant laboratory safety procedures.
-Avoid direct contact with skin and inhalation of dust during operation, and ensure good ventilation.
-It is recommended that appropriate protective gloves and respirators be worn when using or handling the NDA.
Nature:
-Appearance: NDA is a yellow crystalline solid.
-Solubility: NDA is soluble in organic solvents such as dichloromethane, dimethyl sulfoxide and dimethylformamide.
-Melting point: The melting point of NDA is about 212-215 degrees Celsius.
Use:
- NDA is an important organic synthesis intermediate, which has a wide range of applications in the fields of medicine and pesticide.
-It can be used to synthesize indole derivatives, which have anti-tumor, antibacterial and anti-inflammatory drug activities.
Preparation Method:
-One commonly used method of preparing NDA is to first alkylate indole under basic conditions to form 2-phenylindole. Then, 2-phenylindole is nitrated in the presence of a strong acid such as nitric acid and sulfuric acid to form 2-phenyl-7-nitro-indole in an oxidized state. Finally, through the carboxylation reaction under acidic conditions, the nitro group is oxidized to carboxyl, and the target product 2-phenyl -7-nitro -5-carboxylic acid indole is prepared.
Safety Information:
- NDA has low toxicity, but it still needs to be used and stored carefully, and follow relevant laboratory safety procedures.
-Avoid direct contact with skin and inhalation of dust during operation, and ensure good ventilation.
-It is recommended that appropriate protective gloves and respirators be worn when using or handling the NDA.
Last Update：2024-04-09 21:00:56
